Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7958215 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2ADAOMAPK1 | |
| SCHEMBL1551334 | 0.84 | HSP90AB1 (0.43) | SMN1; SMN2MEN1KMT2ADAOHTT | |
| SCHEMBL16563717 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2ADAOMAPK1 | |
| SCHEMBL2033883 | 0.80 | CYP1A2 (0.43) | SMN1; SMN2DAOTSHRALDH1A1POLB | |
| SCHEMBL27869621 | 0.79 | CYP4F2 (0.50) | SMN1; SMN2MEN1KMT2ADAOMAPK1 | |
| SCHEMBL27942177 | 0.79 | DAO (0.47) | SMN1; SMN2MEN1KMT2ADAOMAPK1 | |
| SCHEMBL28628107 | 0.79 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1KMT2AMAPK1HTT | |
| SCHEMBL6167651 | 0.78 | DAO (0.42) | SMN1; SMN2MEN1KMT2ADAOMAPK1 | |
| SCHEMBL6168905 | 0.77 | DAO (0.45) | SMN1; SMN2MEN1KMT2ADAOMAPK1 | |
| SCHEMBL1551106 | 0.77 | DAO (0.50) | SMN1; SMN2MEN1KMT2ADAOGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2848617-B1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-01-12 | — | — | EP | disclosed |
| US-9751882-B2 | Diaryl[A, G]quinolizidine compound, preparation method therefor, pharmaceutical composition, and uses thereof | KINGSOUND & PARTNER (CN) | 2017-09-05 | — | — | US | disclosed |
| US-9376417-B2 | Process for preparing aryl- and heteroarylacetic acid derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20150315171-A1 | PROCESS FOR PREPARING ARYL - AND HETEROARYLACETIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2015-11-05 | — | — | US | disclosed |
| US-9096568-B2 | Process for preparing aryl- and heteroarylacetic acid derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2015-08-04 | — | — | US | disclosed |
| US-20150141419-A1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2015-05-21 | — | — | US | disclosed |
| EP-2848617-A1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2015-03-18 | — | — | EP | disclosed |
| US-20140155632-A1 | PROCESS FOR PREPARING ARYL- AND HETEROARYLACETIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2014-06-05 | — | — | US | disclosed |
| EP-1107756-A4 | NOVEL ISOXAZOLINONE ANTIBACTERIAL AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2003-02-26 | — | — | EP | disclosed |
| US-20020094984-A1 | Novel isoxazolinone antibacterial agents | SNYDER LAWRENCE B (US) | 2002-07-18 | — | — | US | disclosed |
| US-6420349-B1 | POTENT ANTIBIOTIC ACTIVE AGAINST GRAM-POSITIVE BACTERIA; ANIMAL FEED;FOOD PRESERVATIVES; WATERBASED PAINTS; WHITE WATER OF PAPER MILLS; DISINFECTANTS FOR MEDICAL AND DENTAL EQUIPMENT | BRISTOL-MYERS SQUIBB COMPANY | 2002-07-16 | — | — | US | disclosed |
| EP-1107756-A1 | NOVEL ISOXAZOLINONE ANTIBACTERIAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000010566-A1 | NOVEL ISOXAZOLINONE ANTIBACTERIAL AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-03-02 | — | — | WO | disclosed |
| US-4159986-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | ROUSSEL UCLAF (FR) | 1979-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141419-A1 | DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF | HTR5A, HTR1F, QDPR | SMN1; SMN2 4618/4885MEN1 2484/4885KMT2A 3312/4885 |
| US-20140155632-A1 | PROCESS FOR PREPARING ARYL- AND HETEROARYLACETIC ACID DERIVATIVES | DDC, AHR, DDT | SMN1; SMN2 4321/4885MEN1 2950/4885KMT2A 448/4885 |
| US-20020094984-A1 | Novel isoxazolinone antibacterial agents | RPS4X, RPS4Y1, CYP51A1 | SMN1; SMN2 2607/4885MEN1 3001/4885KMT2A 4244/4885 |
| US-20150315171-A1 | PROCESS FOR PREPARING ARYL - AND HETEROARYLACETIC ACID DERIVATIVES | DDC, AHR, DDT | SMN1; SMN2 4321/4885MEN1 2950/4885KMT2A 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.