SCHEMBL1551523

SCHEMBL1551523

COC(=O)CCc1ccc(C#Cc2cc(C)ccc2C)cc1

nearest known ligand 0.74

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 20/20 0.74
CHRM2 P08172 1/20 0.52
S1PR1 P21453 1/20 0.52
FPR1 P21462 1/20 0.52
FPR3 P25089 1/20 0.52
GPR183 P32249 1/20 0.52
APLNR P35414 1/20 0.52
FFAR4 Q5NUL3 1/20 0.52
GPR65 Q8IYL9 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1550285 0.86 FFAR1 (0.69) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL1550924 0.85 FFAR1 (1.00) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL1551052 0.84 FFAR1 (0.73) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL1550386 0.82 FFAR1 (0.71) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL1551097 0.82 FFAR1 (0.74) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL1550283 0.82 FFAR1 (0.73) FFAR1FFAR4
SCHEMBL1550669 0.78 FFAR1 (0.68) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL1551436 0.78 FFAR1 (0.54) FFAR1
SCHEMBL1551069 0.77 FFAR1 (0.72) FFAR1CHRM2S1PR1FPR1FPR3
SCHEMBL2569441 0.77 L3MBTL1 (0.55) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105152919-A Compounds for the treatment of metabolic diseases UNIV SYDDANSK 2015-12-16 CN disclosed
CN-102137836-B Compounds for the treatment of metabolic disorders SYDDANSK UNIVERSITET (DK) 2015-08-26 CN disclosed
US-8586607-B2 Compounds for the treatment of metabolic diseases SYDDANSK UNIVERSITET (DK) 2013-11-19 US disclosed
US-8586607-B2 Compounds for the treatment of metabolic diseases SYDDANSK UNIVERSITET (DK) 2013-11-19 US disclosed
EP-2313360-B1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES UNIV SYDDANSK (DK) 2012-09-05 EP disclosed
EP-2313360-B1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES UNIV SYDDANSK (DK) 2012-09-05 EP disclosed
US-20110152315-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES SYDDANSK UNIVERSITET 2011-06-23 US disclosed
US-20110152315-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES SYDDANSK UNIVERSITET 2011-06-23 US disclosed
EP-2313360-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES Syddansk Universitet (DK) 2011-04-27 EP disclosed
WO-2010012650-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES SYDDANSK UNIVERSITET (DK) 2010-02-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152315-A1 COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES GPR119, INSR, GPR65 FFAR1 6/4885CHRM2 580/4885S1PR1 370/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.