Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.40 |
| ▸ | LPL | P06858 | 8/20 | 0.40 |
| ▸ | F11 | P03951 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.32 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15518375 | 0.86 | LPL (0.40) | LIPGLPLF11ESR2 | |
| SCHEMBL21612866 | 0.77 | CA9 (0.36) | CA1CA2CA9 | |
| SCHEMBL23801191 | 0.77 | HIF1A (0.41) | — | |
| SCHEMBL14986010 | 0.76 | CHKA (0.35) | LIPGLPLF11PRSS1PRSS2 | |
| SCHEMBL1285032 | 0.76 | LIPG (0.65) | LIPGLPLF11ESR2F2 | |
| SCHEMBL21612867 | 0.75 | CA1 (0.35) | CA1CA2CA9 | |
| SCHEMBL21612887 | 0.75 | P4HB (0.49) | ESR2CA1CA2CA9 | |
| SCHEMBL30188573 | 0.73 | P4HB (0.42) | — | |
| SCHEMBL30188658 | 0.73 | AAK1 (0.43) | — | |
| SCHEMBL21612862 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139576-B2 | Aminomethyl biaryl benzotriazole derivatives | MERCK SHARP & DOHME CORP. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | MERCK SHARP & DOHME LLC | 2014-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066443-A1 | AMINOMETHYL BIARYL BENZOTRIAZOLE DERIVATIVES | GRM2, GRM3, GRIN2C | LIPG 4225/4885LPL 3678/4885F11 4808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.