Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.34 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163920 | 0.82 | LMNA (0.40) | POLBAPEX1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL3520677 | 0.79 | POLB (0.46) | POLBAPEX1TDP1L3MBTL1HDAC4 | |
| SCHEMBL13278800 | 0.77 | MAPT (0.39) | L3MBTL1ALDH1A1LDHALMNAMAPT | |
| SCHEMBL13278718 | 0.77 | ALDH1A1 (0.41) | ALDH1A1MAPT | |
| SCHEMBL8095132 | 0.69 | — | — | |
| SCHEMBL4960652 | 0.68 | POLB (0.47) | POLBAPEX1TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL782203 | 0.67 | — | — | |
| SCHEMBL28878976 | 0.67 | — | — | |
| SCHEMBL1147718 | 0.67 | — | — | |
| SCHEMBL4334753 | 0.67 | TDP1 (0.46) | POLBAPEX1TDP1L3MBTL1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906534-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | Grünenthal GmbH (DE) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014032801-A1 | FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES | Grünenthal GmbH (DE) | 2014-03-06 | — | — | WO | disclosed |