Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | LPL | P06858 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468657 | 0.82 | TAAR1 (0.55) | TAAR1TDP1HDAC2PGRERN1 | |
| SCHEMBL24196355 | 0.82 | ALDH1A1 (0.57) | TAAR1TDP1HDAC2PGRERN1 | |
| SCHEMBL26423596 | 0.81 | TAAR1 (0.53) | TAAR1MEN1KMT2ATDP1HDAC2 | |
| SCHEMBL24714531 | 0.80 | TAAR1 (0.52) | TAAR1HDAC2PGRERN1ADORA2A | |
| SCHEMBL30820503 | 0.78 | ADORA2A (0.56) | TAAR1MEN1KMT2AERN1ADORA2A | |
| SCHEMBL12121599 | 0.78 | ERN1 (0.62) | TAAR1HDAC2PGRERN1ADORA2A | |
| SCHEMBL19475516 | 0.78 | ADORA2A (0.56) | TAAR1MEN1KMT2AERN1ADORA2A | |
| SCHEMBL394300 | 0.77 | TAAR1 (0.76) | TAAR1MEN1KMT2ATDP1PGR | |
| SCHEMBL23154128 | 0.76 | HDAC2 (0.49) | TAAR1HDAC2PGRERN1KEAP1 | |
| SCHEMBL1161258 | 0.76 | TAAR1 (1.00) | TAAR1MEN1KMT2ATDP1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102775356-B | 4-aminoquinazoline derivative and application thereof | JIANGSU HENGYI PHARMACEUTICAL CO LTD | 2015-07-22 | — | — | CN | disclosed |
| US-9034886-B2 | 4-aminoquinazoline derivatives and uses thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2015-05-19 | — | — | US | disclosed |
| WO-2014191358-A1 | NOVEL COMPOUNDS WITH SEMICONDUCTING PROPERTIES | SOLVAY SA (BE) | 2014-12-04 | — | — | WO | disclosed |
| EP-2808373-A1 | Semiconductor materials on the basis of rylene diimide derivatives or napththalene derivatives, and polymers and semiconductor devices comprising said materials | Solvay SA (BE) | 2014-12-03 | — | — | EP | disclosed |
| EP-2808327-A1 | Novel compounds with semiconducting properties | Solvay SA (BE) | 2014-12-03 | — | — | EP | disclosed |
| US-20140235633-A1 | 4-Aminoquinazoline Derivatives and Uses Thereof | SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) | 2014-08-21 | — | — | US | disclosed |
| EP-2708532-A1 | 4-AMINOQUINAZOLINE DERIVATIVES AND USES THEREOF | Jiangsu Hengyi Pharmaceutical Co.,Ltd (CN) | 2014-03-19 | — | — | EP | disclosed |
| CN-102775356-A | 4-aminoquinazoline derivative and application thereof | JIANGSU HENGYI PHARMACEUTICAL CO LTD | 2012-11-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235633-A1 | 4-Aminoquinazoline Derivatives and Uses Thereof | HDAC5, HDAC4, HDAC1 | TAAR1 3337/4885MEN1 3655/4885KMT2A 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.