Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 4/20 | 0.49 |
| ▸ | CTSL | P07711 | 4/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340310 | 0.90 | MEN1 (0.56) | CTSVCTSLCYP19A1KDM4ELMNA | |
| SCHEMBL13936617 | 0.90 | MEN1 (0.56) | CTSVCTSLCYP19A1KDM4ELMNA | |
| SCHEMBL30820477 | 0.88 | CTSV (0.50) | CTSVCTSLCYP19A1KDM4ELMNA | |
| SCHEMBL18660057 | 0.88 | CTSV (0.50) | CTSVCTSLCYP19A1KDM4ELMNA | |
| SCHEMBL7038843 | 0.86 | MAOB (0.53) | CTSVCTSLCYP19A1ALDH1A1MAPT | |
| SCHEMBL8316504 | 0.84 | CTSV (0.61) | CTSVCTSLCYP19A1KDM4EALDH1A1 | |
| SCHEMBL7521404 | 0.82 | HTT (0.56) | LMNACYP3A4TSHRMAPTL3MBTL1 | |
| SCHEMBL873861 | 0.81 | CTSV (0.60) | CTSVCTSLKDM4ELMNAALDH1A1 | |
| SCHEMBL38657998 | 0.81 | LMNA (0.64) | CTSVCTSLCYP19A1KDM4ELMNA | |
| SCHEMBL159283 | 0.81 | CTSV (0.60) | CTSVCTSLKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2392565-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2014-03-19 | — | — | EP | disclosed |