Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | USP9X | Q93008 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 17/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23430681 | 0.88 | DPP4 (0.40) | KDM1AUSP9XDPP4AMY1APTPN1 | |
| SCHEMBL18760087 | 0.85 | USP9X (0.38) | KDM1AUSP9XDPP4AMY1APTPN1 | |
| SCHEMBL25500318 | 0.84 | HDAC8 (0.39) | KDM1AUSP9XDPP4AMY1APTPN1 | |
| SCHEMBL25500337 | 0.84 | USP9X (0.41) | KDM1AUSP9XDPP4AMY1APTPN1 | |
| SCHEMBL20483601 | 0.82 | DPP4 (0.40) | USP9XDPP4KCNH2 | |
| SCHEMBL28044985 | 0.80 | USP9X (0.35) | USP9XKCNH2 | |
| SCHEMBL2364142 | 0.80 | DPP4 (0.41) | USP9XDPP4KCNH2 | |
| SCHEMBL15161199 | 0.78 | DPP4 (0.44) | KDM1ADPP4AMY1APTPN1KCNH2 | |
| SCHEMBL28877856 | 0.77 | HDAC1 (0.42) | KDM1AUSP9X | |
| SCHEMBL30706257 | 0.76 | POLB (0.44) | USP9X |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9181262-B2 | Crystalline forms of a dipeptidyl peptidase-IV inhibitors | MERCK SHARP & DOHME CORP (US) | 2015-11-10 | — | — | US | disclosed |
| US-20150099891-A1 | NOVEL CRYSTALLINE FORMS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LLC | 2015-04-09 | — | — | US | disclosed |
| US-8895603-B2 | Crystalline forms of a dipeptidyl peptidase-IV inhibitor | MERCK SHARP & DOHME CORP. (US) | 2014-11-25 | — | — | US | disclosed |
| US-20140107346-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | MERCK SHARP & DOHME LTD. (GB) | 2014-04-17 | — | — | US | disclosed |
| US-20140080884-A1 | NOVEL CRYSTALLINE FORMS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | MERCK SHARP & DOHME LTD. (GB) | 2014-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140107346-A1 | PROCESS FOR PREPARING CHIRAL DIPEPTIDYL PEPTIDASE-IV INHIBITORS | DPP4, DPP7, DPP3 | KDM1A 2447/4885USP9X 1871/4885DPP4 1/4885 |
| US-20150099891-A1 | NOVEL CRYSTALLINE FORMS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITORS | DPP4, DPP3, DPP7 | KDM1A 2000/4885USP9X 1823/4885DPP4 1/4885 |
| US-20140080884-A1 | NOVEL CRYSTALLINE FORMS OF A DIPEPTIDYL PEPTIDASE-IV INHIBITOR | DPP4, DPP3, DPP7 | KDM1A 2052/4885USP9X 1759/4885DPP4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.