SCHEMBL18760087

SCHEMBL18760087

CCS(=O)(=O)n1cc2c(n1)CN(C(=O)O)C2

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
USP9X Q93008 3/20 0.38
DPP4 P27487 5/20 0.37
POLB P06746 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
KDM1A O60341 2/20 0.31
LMNA P02545 1/20 0.31
TSHR P16473 1/20 0.31
SLC6A9 P48067 3/20 0.31
AMY1A P0DUB6 1/20 0.31
PTPN1 P18031 1/20 0.31
KDM4E B2RXH2 2/20 0.30
ALDH1A1 P00352 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28044985 0.86 USP9X (0.35) USP9XSLC6A9
SCHEMBL15524327 0.85 KDM1A (0.39) USP9XDPP4KDM1AAMY1APTPN1
SCHEMBL17380568 0.81 HDAC1 (0.39) DPP4MAPTHTT
SCHEMBL20483601 0.79 DPP4 (0.40) USP9XDPP4SLC6A9
SCHEMBL2364142 0.77 DPP4 (0.41) USP9XDPP4SLC6A9
SCHEMBL9963137 0.75 DPP4 (0.38) DPP4
SCHEMBL28877856 0.74 HDAC1 (0.42) USP9XKDM1ALMNATSHRSLC6A9
SCHEMBL30706257 0.74 POLB (0.44) USP9XPOLBALDH1A1
SCHEMBL30706276 0.73 USP9X (0.39) USP9XMAPTALDH1A1
SCHEMBL23430681 0.73 DPP4 (0.40) USP9XDPP4KDM1AAMY1APTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3159344-B1 AMINO PYRANOID RING DERIVATIVE AND COMPOSITION AND USE THEREOF SICHUAN HAISCO PHARMACEUTICAL CO LTD (CN) 2023-09-20 EP disclosed
US-10065962-B2 Amino pryan ring derivative and composition and use thereof SICHUAN HAISCO PHARMACEUTICAL CO., LTD (CN) 2018-09-04 US disclosed
EP-3159344-A1 AMINO PYRANOID RING DERIVATIVE AND COMPOSITION AND USE THEREOF Sichuan Haisco Pharmaceutical Co., Ltd. (CN) 2017-04-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10065962-B2 Amino pryan ring derivative and composition and use thereof DPP4, DPP8, DPP3 USP9X 2304/4885DPP4 1/4885POLB 3915/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.