Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11669367 | 0.86 | TDP1 (0.42) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL8013907 | 0.78 | TDP1 (0.52) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL273486 | 0.78 | TDP1 (0.52) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL6381049 | 0.75 | TDP1 (0.48) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL20683088 | 0.75 | TDP1 (0.48) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL1879818 | 0.72 | HTT (0.48) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL460599 | 0.71 | TDP1 (0.54) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL10294 | 0.71 | TDP1 (0.48) | TDP1HTTPOLBTNFCYP11B1 | |
| SCHEMBL9060998 | 0.70 | TDP1 (0.48) | TDP1HTTTNFCYP11B1CYP11B2 | |
| SCHEMBL8413080 | 0.70 | TDP1 (0.48) | TDP1HTTPOLBTNFCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2895465-A1 | PARASITICIDAL COMPOSITIONS COMPRISING BENZIMIDAZOLE DERIVATIVES, METHODS AND USES THEREOF | Merial Limited (US) | 2015-07-22 | — | — | EP | disclosed |
| WO-2013158894-A1 | PARASITICIDAL COMPOSITIONS COMPRISING BENZIMIDAZOLE DERIVATIVES, METHODS AND USES THEREOF | MERIAL LIMITED (US) | 2013-10-24 | — | — | WO | disclosed |