Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH5 | P11766 | 3/20 | 0.48 |
| ▸ | EIF4E | P06730 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16651019 | 0.89 | ADH5 (0.48) | ADH5EIF4ESCN9ARARBMAP4K4 | |
| SCHEMBL15526469 | 0.84 | SCN9A (0.53) | ADH5SCN9A | |
| SCHEMBL16650261 | 0.82 | SCN9A (0.42) | SCN9AROCK2ROCK1 | |
| SCHEMBL20794151 | 0.76 | ADH5 (0.50) | ADH5SCN9ARARB | |
| SCHEMBL1131951 | 0.75 | RARB (0.57) | ADH5EIF4ERARBMAP4K4TNKS2 | |
| SCHEMBL18708503 | 0.75 | NPC1 (0.57) | RARBMAP4K4TSHR | |
| SCHEMBL11507830 | 0.74 | RARB (0.63) | ADH5RARBMAP4K4AKR1C3AKR1C2 | |
| SCHEMBL1105964 | 0.74 | HCAR2 (0.47) | TSHRKDM4EALDH1A1NAPRT | |
| SCHEMBL13601689 | 0.74 | TTR (0.50) | EIF4EMAP4K4AKR1C3AKR1C2TNKS2 | |
| SCHEMBL68014 | 0.74 | ALDH1A1 (0.57) | ADH5RARBTSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844252-B1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC COMPOUNDS AS CETP INHIBITORS | MERCK SHARP & DOHME (US) | 2016-11-30 | — | — | EP | disclosed |
| US-9353101-B2 | Cyclic amine substituted heterocyclic CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150111866-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-04-23 | — | — | US | disclosed |
| EP-2844252-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013165854-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111866-A1 | CYCLIC AMINE SUBSTITUTED HETEROCYCLIC CETP INHIBITORS | CETP, APOB, MTTP | ADH5 1825/4885EIF4E 3511/4885SCN9A 2592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.