SCHEMBL15527607

SCHEMBL15527607

NC1C(c2ccccc2)=CC=CC1(N)F

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.33
MAOA P21397 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27605635 0.76
Hydrochloric Acid SCHEMBL27701861 0.75 KDM1A (0.31)
SCHEMBL21698511 0.74 MAOB (0.32) MAOBMAOA
SCHEMBL27446669 0.72
SCHEMBL28055557 0.72
SCHEMBL27728982 0.72 KDM1A (0.33) MAOBMAOA
SCHEMBL28379470 0.66 MAOA (0.41) MAOA
Hydrochloric Acid SCHEMBL6519047 0.64 LMNA (0.33)
SCHEMBL17480245 0.62 ALDH1A1 (0.42) MAOBMAOA
SCHEMBL27503377 0.62 MAOB (0.34) MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2770994-A2 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF Samumed, LLC (US) 2014-09-03 EP disclosed
WO-2013166396-A2 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF SAMUMED, LLC (US) 2013-11-07 WO disclosed