Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.78 |
| ▸ | TTK | P33981 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dnl-201 SCHEMBL4561063 | 0.88 | LRRK2 (1.00) | LRRK2CYP1A2TTK | |
| SCHEMBL15528389 | 0.88 | LRRK2 (0.82) | LRRK2CYP1A2TTK | |
| SCHEMBL16469536 | 0.87 | LRRK2 (1.00) | LRRK2CYP1A2TTK | |
| SCHEMBL20555633 | 0.86 | LRRK2 (0.82) | LRRK2CYP1A2TTK | |
| SCHEMBL24147477 | 0.86 | LRRK2 (0.78) | LRRK2CYP1A2TTK | |
| SCHEMBL24147024 | 0.86 | LRRK2 (0.78) | LRRK2CYP1A2TTK | |
| SCHEMBL16469355 | 0.86 | LRRK2 (0.78) | LRRK2CYP1A2TTK | |
| SCHEMBL24146920 | 0.86 | LRRK2 (0.78) | LRRK2CYP1A2TTK | |
| SCHEMBL18455174 | 0.85 | LRRK2 (0.80) | LRRK2CYP1A2TTK | |
| SCHEMBL4542143 | 0.85 | LRRK2 (0.78) | LRRK2CYP1A2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2844652-B1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2019-03-13 | — | — | EP | claimed |
| US-9212173-B2 | Pyrazole aminopyrimidine derivatives as LRRK2 modulators | GENENTECH, INC. (US) | 2015-12-15 | — | — | US | claimed |
| US-20150051238-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH, INC. (CA) | 2015-02-19 | — | — | US | claimed |
| CN-104271569-A | Pyrazolylaminopyrimidine derivatives as LRRK2 modulators | HOFFMANN LA ROCHE | 2015-01-07 | — | — | CN | claimed |
| EP-2844652-B1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2019-03-13 | — | — | EP | disclosed |
| EP-2844652-B1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH INC (US) | 2019-03-13 | — | — | EP | disclosed |
| CN-106220615-A | Pyrazoles aminopyridine derivative as LRRK2 regulator | 霍夫曼-拉罗奇有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-104271569-B | Pyrazolylaminopyrimidine derivatives as LRRK2 modulators | 霍夫曼-拉罗奇有限公司 | 2016-08-24 | — | — | CN | disclosed |
| US-9212173-B2 | Pyrazole aminopyrimidine derivatives as LRRK2 modulators | GENENTECH, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212173-B2 | Pyrazole aminopyrimidine derivatives as LRRK2 modulators | GENENTECH, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-9212173-B2 | Pyrazole aminopyrimidine derivatives as LRRK2 modulators | GENENTECH, INC. (US) | 2015-12-15 | — | — | US | disclosed |
| EP-2844652-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2015-03-11 | — | — | EP | disclosed |
| US-20150051238-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH, INC. (CA) | 2015-02-19 | — | — | US | disclosed |
| US-20150051238-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH, INC. (CA) | 2015-02-19 | — | — | US | disclosed |
| US-20150051238-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | GENENTECH, INC. (CA) | 2015-02-19 | — | — | US | disclosed |
| US-20150030540-A1 | Imaging agents for detecting neurological dysfunction | LILLY CO ELI (US) | 2015-01-29 | — | — | US | disclosed |
| CN-104271569-A | Pyrazolylaminopyrimidine derivatives as LRRK2 modulators | HOFFMANN LA ROCHE | 2015-01-07 | — | — | CN | disclosed |
| WO-2013164321-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150030540-A1 | Imaging agents for detecting neurological dysfunction | SLC18A3, TSPO, CHAT | LRRK2 2178/4885CYP1A2 2224/4885TTK 3853/4885 |
| US-20150051238-A1 | PYRAZOLE AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | LRRK2, PARK7, PINK1 | LRRK2 1/4885CYP1A2 4275/4885TTK 927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.