Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 17/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.71 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528419 | 0.86 | HDAC1 (0.65) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL15612925 | 0.86 | HDAC1 (0.70) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL15528574 | 0.84 | HDAC1 (0.65) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL28633689 | 0.83 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL15524907 | 0.83 | ALOX5 (0.57) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL15612771 | 0.80 | HDAC6 (0.49) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL19129211 | 0.79 | HDAC6 (0.48) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL15612899 | 0.79 | HDAC1 (0.81) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL21643753 | 0.78 | HDAC1 (0.86) | HDAC1HDAC6HDAC8HDAC3HDAC2 | |
| SCHEMBL28635779 | 0.78 | HDAC1 (0.78) | HDAC1HDAC6HDAC8HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447069-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447069-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447069-B2 | ROR modulators and their uses | INNOV17 LLC (US) | 2016-09-20 | — | — | US | disclosed |
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-04-09 | — | — | US | disclosed |
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-04-09 | — | — | US | disclosed |
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | INNOV17 LLC | 2015-04-09 | — | — | US | disclosed |
| EP-2844260-A1 | ROR MODULATORS AND THEIR USES | Gaweco, Anderson (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013166015-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |
| WO-2013166015-A1 | ROR MODULATORS AND THEIR USES | GAWECO ANDERSON (US) | 2013-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150099779-A1 | ROR MODULATORS AND THEIR USES | RORB, RORA, RORC | HDAC1 460/4885HDAC6 381/4885HDAC8 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.