Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15528336 | 0.82 | PLA2G10 (0.36) | PLA2G10SMN1; SMN2GAAMAPTTSHR | |
| SCHEMBL29148947 | 0.71 | ALDH1A1 (0.40) | PLA2G10ATMGAAL3MBTL1MEN1 | |
| SCHEMBL28550759 | 0.67 | MCL1 (0.44) | PLA2G10GAAMAPTTSHRKDM4E | |
| SCHEMBL29149059 | 0.66 | NR1H2 (0.41) | — | |
| SCHEMBL30988680 | 0.64 | THRA (0.37) | SMN1; SMN2ATMGAAMAPTTSHR | |
| SCHEMBL30419255 | 0.63 | PLA2G10 (0.50) | PLA2G10 | |
| SCHEMBL31462830 | 0.63 | NR1H2 (0.43) | MEN1KMT2A | |
| SCHEMBL2490611 | 0.62 | OXER1 (0.40) | SMN1; SMN2MAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL10233030 | 0.62 | MCL1 (0.57) | PLA2G10SMN1; SMN2GAAMAPTTSHR | |
| SCHEMBL12569955 | 0.62 | ALDH1A1 (0.60) | ATMMAPTTAS2R14L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855456-A1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | Novartis AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013164802-A1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2013-11-07 | — | — | WO | disclosed |