Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30933380 | 1.00 | PLA2G10 (0.36) | PLA2G10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL15528596 | 0.82 | PLA2G10 (0.33) | PLA2G10MEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL29149059 | 0.81 | NR1H2 (0.41) | CA12CA9 | |
| SCHEMBL3847463 | 0.76 | MCL1 (0.45) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL29148947 | 0.75 | ALDH1A1 (0.40) | PLA2G10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL15971081 | 0.72 | KDM4E (0.44) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL28550759 | 0.68 | MCL1 (0.44) | PLA2G10KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31462830 | 0.67 | NR1H2 (0.43) | MEN1KMT2A | |
| SCHEMBL9354562 | 0.66 | CA12 (0.44) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL10233030 | 0.66 | MCL1 (0.57) | PLA2G10KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855456-A1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | Novartis AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013164802-A1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2013-11-07 | — | — | WO | disclosed |