Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | PKM | P14618 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15529231 | 0.83 | MAPT (0.50) | MAPTSMN1; SMN2TP53ALDH1A1NPC1 | |
| SCHEMBL15529237 | 0.81 | ALDH1A1 (0.48) | MAPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL1741960 | 0.72 | MET (0.51) | — | |
| SCHEMBL1742630 | 0.71 | MET (0.47) | MAPTSMN1; SMN2TP53CACNA2D1FGFR1 | |
| SCHEMBL18979213 | 0.70 | MEN1 (0.78) | MAPTSMN1; SMN2TP53ALDH1A1NPC1 | |
| SCHEMBL15528907 | 0.70 | MEN1 (0.78) | MAPTSMN1; SMN2TP53ALDH1A1NPC1 | |
| SCHEMBL4966792 | 0.69 | BCAT2 (0.59) | MAPTSMN1; SMN2TP53ALDH1A1NPC1 | |
| SCHEMBL1533660 | 0.68 | NTRK1 (0.43) | MEN1KMT2AGAAPOLB | |
| SCHEMBL3440767 | 0.68 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL9479637 | 0.68 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846803-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | Anvyl, LLC (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013169889-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ANVYL LLC (US) | 2013-11-14 | — | — | WO | disclosed |