Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.43 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553980 | 0.84 | GAA (0.43) | SMN1; SMN2MAPK1ABL1KDM4EMAPT | |
| SCHEMBL1553271 | 0.81 | CDK8 (0.42) | MAPK1PIK3CAMAPK8MAPK9MAPK10 | |
| SCHEMBL1553044 | 0.81 | HCAR3 (0.56) | HCAR3 | |
| SCHEMBL31243318 | 0.70 | LDHA (0.62) | LDHANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL31243319 | 0.70 | LDHA (0.62) | LDHANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1553979 | 0.69 | — | — | |
| SCHEMBL27991189 | 0.69 | DHODH (0.53) | NPC1RAB9ASMN1; SMN2ABL1KDM4E | |
| SCHEMBL31243321 | 0.69 | LDHA (0.57) | LDHANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL31243320 | 0.69 | LDHA (0.57) | LDHANPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL1552425 | 0.69 | DGAT1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102199-B1 | ANTIBACTERIAL POLYCYCLIC UREA COMPOUNDS | ASTRAZENECA AB (SE) | 2011-04-27 | — | — | EP | disclosed |