Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | CALCRL | Q16602 | 2/20 | 0.52 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NTSR2 | O95665 | 1/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thymoctonan SCHEMBL1230532 | 1.00 | REN (0.52) | RENCALCRLRAMP1OPRK1OPRD1 | |
| SCHEMBL30259604 | 0.97 | REN (0.53) | RENCALCRLRAMP1OPRK1OPRD1 | |
| SCHEMBL2195454 | 0.93 | OPRD1 (0.55) | RENOPRK1OPRD1F2ACE | |
| SCHEMBL31323239 | 0.93 | CALCRL (0.56) | CALCRLRAMP1OPRD1F2OPRM1 | |
| SCHEMBL17456231 | 0.93 | REN (0.51) | RENCALCRLRAMP1OPRK1OPRD1 | |
| SCHEMBL30011888 | 0.91 | OPRM1 (0.55) | RENOPRK1OPRM1KEAP1 | |
| SCHEMBL30603858 | 0.90 | CALCRL (0.53) | CALCRLRAMP1OPRD1F2KEAP1 | |
| SCHEMBL31694408 | 0.90 | F2 (0.58) | CALCRLRAMP1OPRK1OPRD1F2 | |
| SCHEMBL30469507 | 0.88 | F2 (0.56) | CALCRLRAMP1OPRK1OPRD1F2 | |
| SCHEMBL29666135 | 0.86 | OPRK1 (0.58) | RENOPRK1OPRD1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2846788-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | Akron Molecules AG (AT) | 2015-03-18 | — | — | EP | disclosed |
| WO-2013167743-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | AKRON MOLECULES GMBH (AT) | 2013-11-14 | — | — | WO | disclosed |