Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 2/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533699 | 0.86 | CCNB2 (0.43) | CCNB2CDK1RETCCNB1CCNB3 | |
| SCHEMBL15534056 | 0.85 | MEN1 (0.46) | CCNB2CDK1RETCCNB1CCNB3 | |
| SCHEMBL30335652 | 0.81 | PLK1 (0.60) | CCNB2CDK1RETCCNB1CCNB3 | |
| SCHEMBL15533961 | 0.81 | CAMKK2 (0.53) | CCNB2CDK1RETCCNB1CCNB3 | |
| SCHEMBL27113928 | 0.80 | CDK1 (0.54) | CCNB2CDK1RETCCNB1CCNB3 | |
| SCHEMBL15534392 | 0.79 | MAPK8 (0.44) | CCNB2CDK1RETCCNB1CCNB3 | |
| SCHEMBL15534293 | 0.79 | SYK (0.49) | ALDH1A1KDM4EMEN1POLBGAA | |
| SCHEMBL15534289 | 0.78 | SYK (0.59) | PIK3CGPIK3CAPIK3CBGSK3BMAPK8 | |
| SCHEMBL15533886 | 0.78 | CLK1 (0.67) | AURKAKDM4EFLT3GSK3BMAPK8 | |
| SCHEMBL15533688 | 0.77 | TRPV1 (0.50) | AURKAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |