Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28481273 | 0.85 | GFER (0.68) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL948677 | 0.84 | GFER (0.71) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL289605 | 0.84 | POLB (0.74) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL1144650 | 0.82 | GFER (0.68) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL9410743 | 0.81 | GFER (0.71) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL8708978 | 0.81 | GFER (0.67) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL8707863 | 0.81 | GFER (0.67) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL20181880 | 0.81 | ALDH1A1 (0.75) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL8445235 | 0.79 | GFER (1.00) | GFERHTTMAPK14AVPR1APOLB | |
| SCHEMBL8984788 | 0.79 | GFER (0.67) | GFERHTTMAPK14AVPR1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316838-B | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE | 2013-01-30 | — | — | CN | disclosed |
| CN-101316838-B | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE | 2013-01-30 | — | — | CN | disclosed |
| EP-1968967-B1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |
| US-7538101-B2 | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-7538101-B2 | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| CN-101316838-A | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |
| CN-101316838-A | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |
| EP-1968967-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007062997-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | MTNR1A, HTR1A, HRH4 | GFER 2885/4885HTT 713/4885MAPK14 3274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.