Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | BCR | P11274 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108273 | 0.82 | ALDH1A1 (0.68) | CYP1A2CYP2D6HSD17B10CYP3A4CLK4 | |
| SCHEMBL15535216 | 0.79 | MAPT (0.49) | MEN1MAPTKMT2ACYP1A2CYP2D6 | |
| SCHEMBL15533525 | 0.79 | MEN1 (0.62) | MEN1MAPTKMT2ACYP1A2CYP2D6 | |
| SCHEMBL15533534 | 0.78 | THRB (0.58) | MAPTABL1BCRTP53MAPK1 | |
| SCHEMBL5923911 | 0.77 | TRPV1 (0.56) | MEN1KMT2ACYP1A2CYP2D6HSD17B10 | |
| SCHEMBL15533795 | 0.76 | ABL1 (0.64) | MEN1MAPTKMT2ACYP1A2CYP2D6 | |
| SCHEMBL14742745 | 0.76 | MEN1 (1.00) | MEN1MAPTKMT2ACYP1A2MAPK1 | |
| SCHEMBL15533662 | 0.76 | CYP2C19 (0.47) | MEN1MAPTKMT2ACYP1A2CYP2D6 | |
| SCHEMBL27821877 | 0.76 | AHR (0.50) | MEN1MAPTKMT2ACYP1A2CYP2D6 | |
| SCHEMBL15533812 | 0.75 | ALDH1A1 (0.46) | MEN1MAPTKMT2ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |