Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 6/20 | 0.54 |
| ▸ | BCR | P11274 | 6/20 | 0.54 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533795 | 0.87 | ABL1 (0.64) | EGFRABL1BCRTP53TRPV1 | |
| SCHEMBL15533950 | 0.84 | ABL1 (0.47) | ABCG2ABL1BCRTP53TRPV1 | |
| SCHEMBL15533631 | 0.81 | ABL1 (0.46) | ABL1BCRBRAFTP53TRPV1 | |
| SCHEMBL15533814 | 0.81 | ABL1 (0.59) | THRBEGFRABL1BCRBRAF | |
| SCHEMBL15533691 | 0.80 | MAPT (0.47) | ABL1BCRTP53NPSR1LMNA | |
| SCHEMBL4237723 | 0.80 | THRB (0.60) | THRBABCG2EGFRBRAFTP53 | |
| SCHEMBL5923911 | 0.79 | TRPV1 (0.56) | EGFRABL1BCRTP53TRPV1 | |
| SCHEMBL15534241 | 0.79 | CLK1 (0.63) | ABCG2ABL1BCRLMNAMAPT | |
| SCHEMBL15534052 | 0.79 | EGFR (0.55) | ABCG2EGFRTP53TRPV1BACE1 | |
| SCHEMBL15533744 | 0.78 | MEN1 (0.61) | EGFRABL1BCRTP53BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |