Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.51 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.51 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CBFB | Q13951 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20292801 | 0.88 | MALT1 (0.58) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL20741514 | 0.82 | KDM4E (0.64) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL4541208 | 0.80 | ABL1 (0.60) | RAB9AMAPTMEN1KMT2AKDR | |
| SCHEMBL879571 | 0.80 | KDM4E (0.70) | RAB9ANPC1KDM4EMAPTKDR | |
| SCHEMBL23892289 | 0.79 | CYP1A2 (0.46) | KDM4EMEN1KMT2AKDRCYP1A2 | |
| SCHEMBL12298751 | 0.77 | MEN1 (0.56) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL7601178 | 0.76 | HPGDS (0.47) | DYRK1AKDRCYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL4538786 | 0.76 | ALPL (0.51) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL6433457 | 0.76 | NPC1 (0.53) | RAB9ANPC1KDM4EMAPTMEN1 | |
| SCHEMBL16755312 | 0.76 | DYRK1A (0.50) | RAB9ANPC1KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2847192-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-03-18 | — | — | EP | claimed |
| WO-2013170112-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | claimed |
| EP-2847192-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-03-18 | — | — | EP | disclosed |
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |
| WO-2013177253-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-11-28 | — | — | WO | disclosed |
| WO-2013170112-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |