Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.63 |
| ▸ | HBB | P68871 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 4/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5943052 | 0.83 | MAPK1 (0.44) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL13639123 | 0.81 | KDM4E (0.64) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL7802245 | 0.81 | KDM4E (0.59) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL8356790 | 0.79 | ALDH1A1 (0.61) | MEN1KMT2AALDH1A1HSD17B10RAB9A | |
| SCHEMBL20931739 | 0.79 | KDM4E (0.73) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL15533773 | 0.78 | MEN1 (0.38) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL9899761 | 0.78 | ALOX5 (0.53) | KDM4EMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL8364512 | 0.77 | MAOB (0.56) | MEN1KMT2AALDH1A1POLBTAAR1 | |
| SCHEMBL26218121 | 0.77 | TAAR1 (0.50) | KDM4EALDH1A1HSD17B10TAAR1 | |
| SCHEMBL15177154 | 0.75 | MAPK1 (0.47) | KDM4EMEN1KMT2AALDH1A1BRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852589-A1 | TRIAZOLES AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013175215-A1 | TRIAZOLES AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2013-11-28 | — | — | WO | disclosed |