Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.64 |
| ▸ | HBB | P68871 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534280 | 0.81 | KDM4E (0.63) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL13981842 | 0.81 | ALDH1A1 (0.41) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL13639122 | 0.79 | L3MBTL1 (0.50) | MEN1KMT2AALDH1A1POLBMAPK1 | |
| SCHEMBL7802245 | 0.78 | KDM4E (0.59) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL20931739 | 0.77 | KDM4E (0.73) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL6506490 | 0.73 | KDM4E (0.68) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL30354852 | 0.73 | KDM4E (0.68) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL14782127 | 0.73 | KDM4E (0.68) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL26227149 | 0.73 | KDM4E (0.68) | KDM4EMEN1KMT2AALDH1A1BRCA1 | |
| SCHEMBL1979734 | 0.72 | KDM4E (0.67) | KDM4EMEN1KMT2AALDH1A1BRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304557-B2 | Fused heterocycle derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-11-06 | — | — | US | disclosed |
| US-20090163488-A1 | FUSED HETEROCYCLE DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163488-A1 | FUSED HETEROCYCLE DERIVATIVES AND USE THEREOF | NOX3, NOX5, ZYX | KDM4E 2148/4885MEN1 604/4885KMT2A 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.