SCHEMBL15535208

SCHEMBL15535208

COc1ccc(/C=C/c2c(C#N)cc(O)c(O)c2C#N)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RELA Q04206 3/20 0.49
NQO2 P16083 3/20 0.49
PTGS2 P35354 5/20 0.48
ALOX5 P09917 4/20 0.48
PTGS1 P23219 3/20 0.48
CYP1A1 P04798 3/20 0.48
CYP1B1 Q16678 3/20 0.48
KDM4E B2RXH2 2/20 0.48
LMNA P02545 1/20 0.48
ALOX12 P18054 1/20 0.48
NFE2L2 Q16236 1/20 0.47
CYP19A1 P11511 3/20 0.45
ESR1 P03372 2/20 0.43
ABL1 P00519 2/20 0.43
TTR P02766 2/20 0.43
ABCB1 P08183 2/20 0.43
BCR P11274 2/20 0.43
AHR P35869 2/20 0.43
CYP1A2 P05177 1/20 0.43
TUBB4A P04350 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15535210 1.00 RELA (0.49) RELANQO2PTGS2ALOX5PTGS1
SCHEMBL16969070 0.88 NFE2L2 (0.49) RELANQO2PTGS2ALOX5PTGS1
SCHEMBL16969069 0.88 NFE2L2 (0.49) RELANQO2PTGS2ALOX5PTGS1
SCHEMBL15535053 0.85 PTGS1 (0.45) RELAPTGS2ALOX5PTGS1NFE2L2
SCHEMBL15535055 0.85 PTGS1 (0.45) RELAPTGS2ALOX5PTGS1NFE2L2
SCHEMBL15535674 0.82 TTR (0.40) PTGS2ALOX5PTGS1KDM4EALOX12
SCHEMBL15535673 0.82 TTR (0.40) PTGS2ALOX5PTGS1KDM4EALOX12
SCHEMBL15548535 0.79 NQO2 (0.49) NQO2PTGS2PTGS1CYP1A1CYP1B1
SCHEMBL15548537 0.79 NQO2 (0.49) NQO2PTGS2PTGS1CYP1A1CYP1B1
SCHEMBL5411725 0.78 RELA (0.55) RELANQO2PTGS2ALOX5PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855426-B1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORP (FI) 2017-01-04 EP claimed
US-9458128-B2 Catechol O-methyltransferase activity inhibiting compounds ORION CORPORATION (FI) 2016-10-04 US claimed
US-20150218124-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORPORATION (FI) 2015-08-06 US claimed
EP-2855426-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS Orion Corporation (FI) 2015-04-08 EP claimed
WO-2013175053-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORPORATION (FI) 2013-11-28 WO claimed
US-20220047540-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORP (FI) 2022-02-17 US disclosed
US-20200352898-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORP (FI) 2020-11-12 US disclosed
US-20190029990-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORP (FI) 2019-01-31 US disclosed
US-20170165219-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORP (FI) 2017-06-15 US disclosed
EP-2855426-B1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORP (FI) 2017-01-04 EP disclosed
US-9458128-B2 Catechol O-methyltransferase activity inhibiting compounds ORION CORPORATION (FI) 2016-10-04 US disclosed
US-20150218124-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORPORATION (FI) 2015-08-06 US disclosed
EP-2855426-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS Orion Corporation (FI) 2015-04-08 EP disclosed
WO-2013175053-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS ORION CORPORATION (FI) 2013-11-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170165219-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS COMT, PNMT, HNMT RELA 2047/4885NQO2 131/4885PTGS2 1655/4885
US-20200352898-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS COMT, PNMT, HNMT RELA 2047/4885NQO2 131/4885PTGS2 1655/4885
US-20190029990-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS COMT, PNMT, HNMT RELA 2047/4885NQO2 131/4885PTGS2 1655/4885
US-20150218124-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS COMT, PNMT, HNMT RELA 2047/4885NQO2 131/4885PTGS2 1655/4885
US-20220047540-A1 CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS COMT, PNMT, HNMT RELA 2047/4885NQO2 131/4885PTGS2 1655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.