Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544865 | 0.78 | LMNA (0.35) | LMNAMAPTHSD17B10ADORA2BALDH1A1 | |
| SCHEMBL1527119 | 0.73 | TSHR (0.39) | LMNAHSD17B10ADORA2BALDH1A1KDM4E | |
| SCHEMBL23403850 | 0.62 | BRD4 (0.34) | KDM4E | |
| SCHEMBL7020240 | 0.61 | ADORA2B (0.62) | LMNAMAPTADORA2BALDH1A1 | |
| SCHEMBL11720340 | 0.60 | LMNA (0.40) | LMNAMAPTHSD17B10ADORA2BALDH1A1 | |
| SCHEMBL13560809 | 0.58 | KDM4E (0.45) | LMNAMAPTHSD17B10NPSR1ALDH1A1 | |
| SCHEMBL16334986 | 0.58 | GPR35 (0.30) | GPR35 | |
| SCHEMBL3450311 | 0.58 | GPR35 (0.37) | LMNAGPR35HPGD | |
| SCHEMBL23536738 | 0.58 | KDM4E (0.40) | HSD17B10ALDH1A1KDM4EHPGD | |
| SCHEMBL21957490 | 0.57 | HSD17B10 (0.36) | LMNAMAPTHSD17B10NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875006-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | Fondazione Istituto Italiano Di Tecnologia (IT) | 2015-05-27 | — | — | EP | disclosed |
| WO-2013178576-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2013-12-05 | — | — | WO | disclosed |