Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | FABP4 | P15090 | 2/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31370748 | 1.00 | KDM4E (0.40) | KDM4EALDH1A1KMT2ATHRBMEN1 | |
| SCHEMBL1777460 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1POLBHPGDHSD17B10 | |
| SCHEMBL21805281 | 0.79 | CDK9 (0.36) | AKR1C3 | |
| SCHEMBL6123415 | 0.78 | KDM4E (0.41) | KDM4EALDH1A1KMT2ATHRBMEN1 | |
| SCHEMBL2594979 | 0.77 | TFPI2 (0.54) | KDM4EALDH1A1KMT2ATHRBMEN1 | |
| SCHEMBL28829688 | 0.77 | ALDH1A1 (0.50) | KDM4EALDH1A1KMT2ATHRBMEN1 | |
| SCHEMBL30622597 | 0.77 | TFPI2 (0.54) | KDM4EALDH1A1KMT2ATHRBMEN1 | |
| SCHEMBL5814849 | 0.77 | ALDH1A1 (0.44) | KDM4EALDH1A1KMT2ATHRBAKR1C3 | |
| SCHEMBL15565511 | 0.76 | SMN1; SMN2 (0.41) | KDM4EALDH1A1KMT2APOLBHSD17B10 | |
| SCHEMBL2544694 | 0.76 | L3MBTL1 (0.52) | KDM4EALDH1A1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127333-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| CN-101595121-A | Pyrrolidine derivatives as IAP inhibitors | NOVARTIS AG (CH) | 2009-12-02 | — | — | CN | disclosed |