SCHEMBL15539405

SCHEMBL15539405

CC(C)(F)CN1CCC(COc2ccc(-c3cccc(F)c3C(=O)N3C[C@@H](F)C[C@H]3C(N)=O)cc2)CC1

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 4/20 0.43
SCN9A Q15858 1/20 0.38
LMNA P02545 1/20 0.36
MAOA P21397 5/20 0.36
MAOB P27338 5/20 0.36
ACHE P22303 1/20 0.35
SSTR5 P35346 1/20 0.35
KCNH2 Q12809 1/20 0.35
FFAR4 Q5NUL3 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15552567 0.93 CNR2 (0.39) CNR2LMNAMAOAMAOBACHE
SCHEMBL16758146 0.93 CNR2 (0.43) CNR2SCN9ALMNAMAOAMAOB
SCHEMBL15539842 0.93 CNR2 (0.39) CNR2LMNAMAOAMAOBACHE
SCHEMBL15537536 0.93 SCN9A (0.45) CNR2SCN9ALMNAACHESSTR5
SCHEMBL15540203 0.93 SCN9A (0.45) CNR2SCN9ALMNAACHESSTR5
SCHEMBL16777348 0.92 SCN9A (0.38) CNR2SCN9ALMNAACHESSTR5
SCHEMBL15539101 0.89 SCN9A (0.42) CNR2SCN9A
SCHEMBL15539344 0.89 SCN9A (0.42) CNR2SCN9A
SCHEMBL15540341 0.88 CNR2 (0.41) CNR2SCN9AACHE
SCHEMBL15540077 0.88 CNR2 (0.41) CNR2SCN9AACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2858986-B1 PIPERIDINE DERIVATIVES AS GPR119 AGONISTS CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2019-10-30 EP claimed
US-20150166480-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2015-06-18 US claimed
EP-2858986-B1 PIPERIDINE DERIVATIVES AS GPR119 AGONISTS CHONG KUN DANG PHARMACEUTICAL CORP (KR) 2019-10-30 EP disclosed
US-9944600-B2 Piperidine derivatives for GPR119 agonist CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2018-04-17 US disclosed
US-20150166480-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2015-06-18 US disclosed
EP-2858986-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST Chong Kun Dang Pharmaceutical Corp. (KR) 2015-04-15 EP disclosed
WO-2013187646-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2013-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150166480-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST GPR119, FFAR2, GPR84 CNR2 42/4885SCN9A 746/4885LMNA 4164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.