Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | ACHE | P22303 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554388 | 0.88 | CA1 (0.47) | CA1CA2ACHEKMT2AMEN1 | |
| SCHEMBL1553334 | 0.80 | NQO2 (0.42) | LMNASYKCTSSCTSK | |
| SCHEMBL1554043 | 0.79 | CA1 (0.47) | CA1CA2ACHEKMT2AMEN1 | |
| SCHEMBL1554728 | 0.76 | SYK (0.47) | CA1CA2ACHEL3MBTL1LMNA | |
| SCHEMBL1554809 | 0.76 | CA1 (0.58) | CA1CA2ACHEL3MBTL1LMNA | |
| SCHEMBL15317909 | 0.76 | SMN1; SMN2 (0.62) | KMT2AL3MBTL1LMNASMN1; SMN2SYK | |
| SCHEMBL13569333 | 0.76 | SMN1; SMN2 (0.62) | KMT2AL3MBTL1LMNASMN1; SMN2SYK | |
| SCHEMBL3226529 | 0.76 | SMN1; SMN2 (0.62) | KMT2AL3MBTL1LMNASMN1; SMN2SYK | |
| SCHEMBL4443866 | 0.75 | AOC3 (0.55) | L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL9765283 | 0.75 | LMNA (0.45) | L3MBTL1LMNASMN1; SMN2SYKHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044195-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |