Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554388 | 0.89 | CA1 (0.47) | NPC1RAB9ASMN1; SMN2LTA4HL3MBTL1 | |
| SCHEMBL1555588 | 0.88 | SYK (0.49) | SYKNPC1RAB9ASMN1; SMN2BCL2 | |
| SCHEMBL12322222 | 0.84 | SYK (0.54) | SYKPPARABCHECNR2CA1 | |
| SCHEMBL1554726 | 0.82 | GPR88 (0.52) | SYKNPC1RAB9ASMN1; SMN2BCL2 | |
| SCHEMBL1553476 | 0.82 | SYK (0.54) | SYKNPC1RAB9ASMN1; SMN2BCL2 | |
| SCHEMBL1553334 | 0.81 | NQO2 (0.42) | SYKADRB2ADRB1ADRB3LMNA | |
| SCHEMBL4582959 | 0.81 | DRD2 (0.49) | SYKADRB2ADRB1ADRB3LMNA | |
| SCHEMBL23684597 | 0.81 | SYK (0.51) | SYKSMN1; SMN2ADRB2ADRB3BCHE | |
| SCHEMBL13191491 | 0.81 | PPARA (0.48) | NPC1RAB9ASMN1; SMN2HDAC1L3MBTL1 | |
| SCHEMBL2172395 | 0.80 | LTA4H (0.49) | MRGPRX4LTA4HTNFNOD2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044195-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |