Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554860 | 0.85 | NQO2 (0.44) | NQO2LMNATSHRSYKSERPINE1 | |
| SCHEMBL4582959 | 0.84 | DRD2 (0.49) | LMNACYP1A2TSHRCYP2C19ADORA3 | |
| SCHEMBL1554728 | 0.81 | SYK (0.47) | LMNACYP1A2TSHRCYP2C19ADORA3 | |
| SCHEMBL1554044 | 0.80 | CA1 (0.47) | LMNASYKCTSSCTSK | |
| SCHEMBL1553332 | 0.78 | GPR88 (0.40) | NQO2ALDH1A1GAAAPPCTSS | |
| SCHEMBL2011966 | 0.77 | SMN1; SMN2 (0.51) | NQO2LMNATSHRSYKSERPINE1 | |
| SCHEMBL1553366 | 0.77 | SMN1; SMN2 (0.51) | NQO2LMNATSHRSYKSERPINE1 | |
| SCHEMBL9149377 | 0.77 | SERPINE1 (0.44) | NQO2LMNATSHRSYKSERPINE1 | |
| SCHEMBL13997819 | 0.77 | DRD2 (0.42) | LMNACYP1A2TSHRCYP2C19ADORA3 | |
| SCHEMBL2940084 | 0.76 | NQO2 (0.48) | NQO2ALDH1A1GAAAPPDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044195-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |