Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.36 |
| ▸ | HTR2A | P28223 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12764490 | 0.87 | MAPK14 (0.41) | HTR2APTGER1IDO1 | |
| SCHEMBL11308859 | 0.83 | IDO1 (0.40) | MEN1KMT2ASLC6A4HTR2ASRC | |
| SCHEMBL15544922 | 0.83 | MMP2 (0.42) | MEN1KMT2AHTR2CSLC6A4HTR2A | |
| SCHEMBL12133275 | 0.80 | MRGPRX4 (0.43) | MRGPRX4SLC6A4HTR2ASRCIDO1 | |
| SCHEMBL10108789 | 0.80 | NOS3 (0.36) | FFAR4MEN1KMT2ASRCIDO1 | |
| SCHEMBL19268067 | 0.80 | ALDH1A1 (0.44) | MEN1KMT2ASRCIDO1LMNA | |
| SCHEMBL47975 | 0.79 | IDO1 (0.58) | FFAR4MRGPRX4IDO1MAPK1TDP1 | |
| SCHEMBL19268066 | 0.77 | CYP4F2 (0.44) | FFAR4MRGPRX4SRCIDO1MAPT | |
| SCHEMBL29292701 | 0.76 | IDO1 (0.38) | FFAR4MEN1KMT2ASRCIDO1 | |
| SCHEMBL16724088 | 0.76 | PYCR1 (0.40) | SRCIDO1LMNAKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885307-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014006585-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2014-01-09 | — | — | WO | disclosed |