Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 10/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14841999 | 0.90 | OPRM1 (0.45) | FASNOPRM1SIGMAR1 | |
| SCHEMBL15543650 | 0.88 | OPRM1 (0.42) | FASNOPRM1SIGMAR1KCNH2 | |
| SCHEMBL15544705 | 0.88 | FASN (0.40) | FASNOPRM1SIGMAR1KCNH2SSTR5 | |
| SCHEMBL15543526 | 0.84 | FASN (0.39) | FASNOPRM1SIGMAR1KCNH2SSTR5 | |
| SCHEMBL15544411 | 0.83 | SIGMAR1 (0.52) | FASNOPRM1SIGMAR1KCNH2KDM4E | |
| SCHEMBL15543477 | 0.82 | SIGMAR1 (0.40) | FASNOPRM1SIGMAR1KCNH2SSTR5 | |
| SCHEMBL15544845 | 0.82 | FASN (0.39) | FASNOPRM1SIGMAR1KCNH2 | |
| SCHEMBL14720324 | 0.82 | SIGMAR1 (0.44) | FASNOPRM1SIGMAR1KCNH2 | |
| SCHEMBL14842007 | 0.80 | FASN (0.40) | FASNOPRM1SIGMAR1KCNH2 | |
| SCHEMBL15543614 | 0.79 | FASN (0.65) | FASNOPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014008223-A2 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2014-01-09 | — | — | WO | disclosed |