Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | HTR2A | P28223 | 7/20 | 0.41 |
| ▸ | DRD2 | P14416 | 6/20 | 0.41 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | FASN | P49327 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14841999 | 0.90 | OPRM1 (0.45) | SIGMAR1OPRM1FASN | |
| SCHEMBL15544845 | 0.88 | FASN (0.39) | SIGMAR1OPRM1KCNH2FASN | |
| SCHEMBL14720314 | 0.83 | SIGMAR1 (0.56) | SIGMAR1OPRM1KCNH2FASN | |
| SCHEMBL15544449 | 0.82 | FASN (0.40) | SIGMAR1OPRM1KCNH2FASN | |
| SCHEMBL14842007 | 0.81 | FASN (0.40) | SIGMAR1OPRM1KCNH2FASN | |
| SCHEMBL15544705 | 0.80 | FASN (0.40) | SIGMAR1OPRM1KCNH2FASN | |
| SCHEMBL15543650 | 0.80 | OPRM1 (0.42) | SIGMAR1OPRM1KCNH2DRD2FASN | |
| SCHEMBL14720426 | 0.79 | FASN (0.64) | SIGMAR1OPRM1KCNH2HTR2ADRD2 | |
| SCHEMBL4534373 | 0.78 | FASN (0.51) | FASN | |
| SCHEMBL14720191 | 0.77 | OPRM1 (0.46) | OPRM1FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2744333-A1 | FATTY ACID SYNTHASE INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013028447-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |