Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.45 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.45 |
| ▸ | GRM5 | P41594 | 4/20 | 0.41 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.41 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7179331 | 0.82 | PARP10 (0.58) | PARP10PARP11ALDH1A1NPC1MAPT | |
| SCHEMBL15543967 | 0.78 | HTR7 (0.43) | PARP10PARP11GRM5GRM1ALDH1A1 | |
| SCHEMBL6206012 | 0.77 | KDR (0.47) | PARP10PARP11CYP11B1CYP11B2 | |
| SCHEMBL16406400 | 0.76 | PARP10 (0.50) | PARP10PARP11ALDH1A1NPC1MAPT | |
| SCHEMBL2385433 | 0.74 | PARP1 (0.44) | PARP10PARP11ALDH1A1NPC1TP53 | |
| SCHEMBL12306712 | 0.74 | MEN1 (0.43) | PARP10PARP11ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4611498 | 0.73 | ADRA1A (0.48) | PARP10PARP11GRM5ALDH1A1NPC1 | |
| SCHEMBL29845432 | 0.73 | CLK4 (0.57) | PARP10PARP11PKN2CDC7PIK3CD | |
| SCHEMBL23273185 | 0.72 | PARP10 (0.54) | PARP10PARP11 | |
| SCHEMBL7587251 | 0.72 | PARP10 (0.54) | PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493434-B2 | Substituted indenes as medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2016-11-15 | — | — | US | disclosed |
| US-9493434-B2 | Substituted indenes as medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2016-11-15 | — | — | US | disclosed |
| US-9493434-B2 | Substituted indenes as medicaments | LABORATORIOS DEL DR. ESTEVE S.A. (ES) | 2016-11-15 | — | — | US | disclosed |
| EP-2870145-B1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-21 | — | — | EP | disclosed |
| EP-2870145-B1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE LABOR DR (ES) | 2016-09-21 | — | — | EP | disclosed |
| US-20150158831-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-11 | — | — | US | disclosed |
| US-20150158831-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-11 | — | — | US | disclosed |
| US-20150158831-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2015-06-11 | — | — | US | disclosed |
| EP-2870145-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014006071-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014006071-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2014-01-09 | — | — | WO | disclosed |
| EP-2682391-A1 | Indene derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | disclosed |
| EP-2682391-A1 | Indene derivatives, their preparation and use as medicaments | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2014-01-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158831-A1 | INDENE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS | SIGMAR1, TMEM97, OPRK1 | PARP10 2288/4885PARP11 2543/4885GRM5 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.