Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15586120 | 0.90 | GAA (0.68) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL5357980 | 0.81 | SIRT6 (0.52) | MAPTALDH1A1LMNASMN1; SMN2POLB | |
| SCHEMBL14785080 | 0.81 | MAPT (0.54) | MAPTGAATDP1ALDH1A1LMNA | |
| SCHEMBL16755433 | 0.81 | MAPT (0.42) | MAPTTDP1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9938525 | 0.79 | ALDH1A1 (0.58) | MAPTALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL7517180 | 0.77 | GAA (0.84) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL9396792 | 0.77 | GAA (0.84) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL15568163 | 0.77 | KDM4E (0.48) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL5393424 | 0.77 | MAPT (0.54) | MAPTALDH1A1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL7807230 | 0.74 | GAA (0.97) | MAPTGAATDP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9345653-B2 | Dye composition comprising a cationic meta-phenylenediamine | L'OREAL (FR) | 2016-05-24 | — | — | US | disclosed |
| US-20150143638-A1 | DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE | L'OREAL (FR) | 2015-05-28 | — | — | US | disclosed |
| EP-2867212-A1 | DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE | L'Oréal (FR) | 2015-05-06 | — | — | EP | disclosed |
| WO-2014005900-A1 | DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE | L'OREAL (FR) | 2014-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150143638-A1 | DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE | TYR, MAOA, CUTA | MAPT 3769/4885GAA 2533/4885TDP1 2609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.