Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15545493 | 1.00 | ALDH1A1 (0.45) | ALDH1A1HTTPKMKMT2AMEN1 | |
| SCHEMBL16680759 | 0.83 | ALDH1A1 (0.43) | ALDH1A1HTTPKMKMT2AMEN1 | |
| SCHEMBL15544924 | 0.81 | ALDH1A1 (0.48) | ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL15544928 | 0.81 | ALDH1A1 (0.48) | ALDH1A1HTTKMT2AMAPT | |
| SCHEMBL15545353 | 0.78 | ALDH1A1 (0.39) | ALDH1A1HTTPKMKMT2AMEN1 | |
| SCHEMBL15544895 | 0.77 | ALDH1A1 (0.41) | ALDH1A1HTTPKMKMT2AMEN1 | |
| SCHEMBL15545143 | 0.75 | ALDH1A1 (0.42) | ALDH1A1HTTKMT2AMEN1MAPT | |
| SCHEMBL15545142 | 0.75 | ALDH1A1 (0.42) | ALDH1A1HTTKMT2AMEN1MAPT | |
| SCHEMBL3648669 | 0.74 | ERN1 (0.50) | ALDH1A1HTTPKMKMT2AMEN1 | |
| SCHEMBL29865611 | 0.72 | HTT (0.50) | ALDH1A1HTTPKMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870144-A1 | OREXIN RECEPTOR ANTAGONISTS | Heptares Therapeutics Limited (GB) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014006402-A1 | OREXIN RECEPTOR ANTAGONISTS | HEPTARES THERAPEUTICS LIMITED (GB) | 2014-01-09 | — | — | WO | disclosed |