Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dorzolamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 18/20 | 0.98 |
| ▸ | CA1 | P00915 | 3/20 | 0.98 |
| ▸ | CA12 | O43570 | 1/20 | 0.98 |
| ▸ | CA3 | P07451 | 1/20 | 0.98 |
| ▸ | AR | P10275 | 1/20 | 0.98 |
| ▸ | CA4 | P22748 | 1/20 | 0.98 |
| ▸ | CA6 | P23280 | 1/20 | 0.98 |
| ▸ | CA5A | P35218 | 1/20 | 0.98 |
| ▸ | CA7 | P43166 | 1/20 | 0.98 |
| ▸ | CA9 | Q16790 | 1/20 | 0.98 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.98 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.98 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dorzolamide SCHEMBL41152 | 1.00 | CA2 (0.98) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL28388851 | 1.00 | CA2 (0.98) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL3314050 | 1.00 | CA2 (0.98) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL4525137 | 0.99 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL4455530 | 0.99 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL12223216 | 0.99 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL12874119 | 0.99 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL3306381 | 0.99 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL9914275 | 0.99 | CA2 (1.00) | CA2CA1CA12CA3AR | |
| Dorzolamide SCHEMBL9914274 | 0.99 | CA2 (1.00) | CA2CA1CA12CA3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9481686-B2 | Process for preparing enantiomerically enriched oxamides | ZACH SYSTEM S.P.A. (IT) | 2016-11-01 | — | — | US | disclosed |
| US-20150191485-A1 | Process for Preparing Enantiomerically Enriched Oxamides | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2015-07-09 | — | — | US | disclosed |
| EP-2870162-A1 | PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED OXAMIDES | ZaCh System S.p.A. (IT) | 2015-05-13 | — | — | EP | disclosed |
| WO-2014005943-A1 | PROCESS FOR PREPARING ENANTIOMERICALLY ENRICHED OXAMIDES | ZACH SYSTEM S.P.A. (IT) | 2014-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191485-A1 | Process for Preparing Enantiomerically Enriched Oxamides | OTC, CYP11B2, QDPR | CA2 162/4885CA1 1608/4885CA12 1271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.