Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.42 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15548462 | 1.00 | CA1 (0.46) | CA1CA2ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL4253063 | 0.77 | CA1 (0.59) | CA1CA2ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL4253058 | 0.77 | CA1 (0.59) | CA1CA2ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL214209 | 0.72 | ALDH1A1 (0.51) | CA1CA2ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL214210 | 0.72 | ALDH1A1 (0.51) | CA1CA2ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL1129761 | 0.70 | ALDH1A1 (0.58) | CA1CA2ALDH1A1SMN1; SMN2TRIM24 | |
| SCHEMBL14051332 | 0.70 | MEN1 (0.44) | CA1CA2ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2012417 | 0.69 | RAB9A (0.48) | ALDH1A1SMN1; SMN2MAPTKDM4EGAA | |
| SCHEMBL9653641 | 0.67 | — | — | |
| SCHEMBL4890466 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MERCK SHARPE & DOHME CORP. | 2015-11-26 | — | — | US | disclosed |
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MERCK SHARPE & DOHME CORP. | 2015-11-26 | — | — | US | disclosed |
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MERCK SHARPE & DOHME CORP. | 2015-11-26 | — | — | US | disclosed |
| EP-2855477-A1 | ISOTOPICALLY LABELED BIARYL UREA COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013181075-A1 | ISOTOPICALLY LABELED BIARYL UREA COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2013-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336948-A1 | Isotopically Labeled Biaryl Urea Compounds | MAPT, SLC14A1, UBTF | CA1 3311/4885CA2 4642/4885ALDH1A1 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.