Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | FPR2 | P25090 | 7/20 | 0.60 |
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15548928 | 0.86 | FPR2 (0.79) | TSHRLMNAFPR2PROKR1ALDH1A1 | |
| SCHEMBL15549025 | 0.82 | TSHR (0.59) | TSHRLMNAFPR2PROKR1ALDH1A1 | |
| SCHEMBL15548819 | 0.79 | FPR2 (0.83) | TSHRLMNAFPR2PROKR1ALDH1A1 | |
| SCHEMBL31212435 | 0.75 | EBP (0.70) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL31212431 | 0.75 | EBP (0.70) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL15548779 | 0.75 | FPR2 (1.00) | FPR2PROKR1 | |
| SCHEMBL15549371 | 0.74 | FPR2 (1.00) | LMNAFPR2PROKR1KMT2A | |
| SCHEMBL9737540 | 0.72 | ALDH1A1 (0.75) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL14470092 | 0.72 | MEN1 (0.81) | TSHRLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL3813872 | 0.72 | MEN1 (0.75) | TSHRLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855449-B1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | TAKEDA PHARMACEUTICALS CO (JP) | 2018-03-07 | — | — | EP | claimed |
| EP-2855449-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | claimed |
| WO-2013179024-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-12-05 | — | — | WO | claimed |
| EP-2855449-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013179024-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-12-05 | — | — | WO | disclosed |