Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | MMP1 | P03956 | 2/20 | 0.56 |
| ▸ | MMP2 | P08253 | 2/20 | 0.56 |
| ▸ | MMP9 | P14780 | 2/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15548332 | 1.00 | HPGD (0.67) | HPGDALDH1A1POLBNPSR1CYP1A2 | |
| SCHEMBL15548925 | 0.85 | CYP1A2 (0.67) | HPGDALDH1A1NPSR1CYP1A2CYP2C19 | |
| SCHEMBL15548924 | 0.85 | CYP1A2 (0.67) | HPGDALDH1A1NPSR1CYP1A2CYP2C19 | |
| SCHEMBL30913220 | 0.84 | SLC6A19 (0.69) | HPGDALDH1A1NPSR1CYP1A2CYP2C19 | |
| SCHEMBL29282139 | 0.84 | SLC6A19 (0.69) | HPGDALDH1A1NPSR1CYP1A2CYP2C19 | |
| SCHEMBL28891851 | 0.83 | NPSR1 (0.79) | HPGDALDH1A1NPSR1CYP1A2CYP2C19 | |
| Cinnamoylglycine SCHEMBL1558162 | 0.82 | KMT2A (0.69) | HPGDALDH1A1POLBNPC1RAB9A | |
| Cinnamoylglycine SCHEMBL1558163 | 0.82 | KMT2A (0.69) | HPGDALDH1A1POLBNPC1RAB9A | |
| SCHEMBL15606032 | 0.82 | HPGD (0.64) | HPGDALDH1A1NPSR1CYP1A2CYP2C19 | |
| SCHEMBL31173406 | 0.81 | MAPT (0.62) | POLBCYP1A2CYP2C19CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150246908-A1 | KLF5 MODULATORS | UNITED STATES PATENT AND TRADEMARK OFFICE | 2015-09-03 | — | — | US | disclosed |
| US-20150246908-A1 | KLF5 MODULATORS | UNITED STATES PATENT AND TRADEMARK OFFICE | 2015-09-03 | — | — | US | disclosed |
| WO-2014018859-A1 | KLF5 MODULATORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-01-30 | — | — | WO | disclosed |
| WO-2014018859-A1 | KLF5 MODULATORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246908-A1 | KLF5 MODULATORS | KLF5, KLF10, SREBF1 | HPGD 4289/4885ALDH1A1 2239/4885POLB 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.