Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.50 |
| ▸ | LPL | P06858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.42 |
| ▸ | P4HB | P07237 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15173051 | 0.88 | MLYCD (0.46) | HPGDTDP1LIPGLPLLMNA | |
| SCHEMBL18274796 | 0.85 | LPL (0.56) | HPGDLIPGLPLTSHRALDH1A1 | |
| SCHEMBL1290866 | 0.84 | P4HB (0.44) | LIPGLPLP4HBPDK2 | |
| SCHEMBL12781285 | 0.82 | LPL (0.49) | HPGDLIPGLPLLMNAALDH1A1 | |
| SCHEMBL20288117 | 0.81 | LIPG (0.50) | LIPGLPLSMN1; SMN2P4HBMAPT | |
| SCHEMBL16687454 | 0.81 | LIPG (0.47) | LIPGLPLP4HB | |
| SCHEMBL15539288 | 0.81 | MLYCD (0.40) | HPGDTDP1LIPGLPLLMNA | |
| SCHEMBL2741830 | 0.80 | P4HB (0.43) | LIPGLPLP4HB | |
| SCHEMBL4782167 | 0.79 | P4HB (0.47) | TDP1LIPGLPLLMNAALDH1A1 | |
| SCHEMBL488896 | 0.79 | P4HB (0.50) | HPGDTDP1LIPGLPLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2858990-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| EP-2858982-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | AbbVie Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2013185284-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBOTT LABORATORIES (US) | 2013-12-19 | — | — | WO | disclosed |
| WO-2013188381-A1 | PYRIDINONE AND PYRIDAZINONE DERIVATIVES | ABBVIE INC. (US) | 2013-12-19 | — | — | WO | disclosed |