Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28832683 | 0.79 | KDM4E (0.47) | SMN1; SMN2LMNAHTTFPR2PROKR1 | |
| SCHEMBL347771 | 0.74 | TSHR (0.44) | LMNAFPR2PROKR1MAPTALDH1A1 | |
| SCHEMBL4126301 | 0.69 | LMNA (0.38) | SMN1; SMN2LMNAHTTMAPTNPC1 | |
| SCHEMBL13180563 | 0.69 | GLS (0.61) | SMN1; SMN2LMNAHTTKDM4EADORA2A | |
| SCHEMBL3322655 | 0.68 | SMN1; SMN2 (0.42) | SMN1; SMN2LMNAHTTKDM4EADORA2A | |
| SCHEMBL2005829 | 0.68 | FPR2 (0.43) | FPR2PROKR1KDM4E | |
| SCHEMBL8649530 | 0.68 | ALDH1A1 (0.54) | SMN1; SMN2LMNAHTTKDM4EADORA2A | |
| SCHEMBL3007153 | 0.66 | KDM4E (0.71) | SMN1; SMN2LMNAHTTKDM4EMAPT | |
| SCHEMBL1745199 | 0.66 | ALDH1A1 (0.39) | FPR2PROKR1MAPTATMGLS | |
| SCHEMBL23134841 | 0.65 | SMN1; SMN2 (0.40) | SMN1; SMN2LMNAHTTKDM4EADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104520292-B | Sulphonylpiperidine derivant and they are for treating the purposes of disease of front dynein mediation | 武田药品工业株式会社 | 2016-09-14 | — | — | CN | disclosed |
| CN-104520292-A | Sulfonyl piperidine derivatives and use for treating prokineticin mediated diseases | TAKEDA PHARMACEUTICAL | 2015-04-15 | — | — | CN | disclosed |
| EP-2855449-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013179024-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-12-05 | — | — | WO | disclosed |