Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | XPO1 | O14980 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12140384 | 0.89 | BRD4 (0.40) | NPSR1MT-CO2BRD4 | |
| SCHEMBL3407971 | 0.83 | CYP3A4 (0.40) | NPC1ALDH1A1PARP1BRD4HSD17B1 | |
| SCHEMBL29004748 | 0.83 | HTR3E (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30455057 | 0.83 | HTR3E (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL2130967 | 0.82 | HDAC1 (0.42) | NPC1ALDH1A1PARP1BRD4RIPK1 | |
| SCHEMBL1010292 | 0.82 | MT-CO2 (0.40) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL551649 | 0.81 | MT-CO2 (0.53) | MAPTALDH1A1GAAMT-CO2POLB | |
| SCHEMBL4288276 | 0.81 | PARP1 (0.44) | PARP1HSD17B1HSD17B2 | |
| SCHEMBL2354804 | 0.80 | L3MBTL1 (0.43) | MAPTALDH1A1NPSR1BRD4 | |
| SCHEMBL7758742 | 0.79 | ALDH1A1 (0.42) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377423-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| EP-2877444-B1 | INHIBITORS OF HISTONE DEACETYLASE | BROAD INST INC (US) | 2020-09-02 | — | — | EP | disclosed |
| US-20180072671-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE, INC. (US) | 2018-03-15 | — | — | US | disclosed |
| US-9790184-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-20150191427-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL (US) | 2015-07-09 | — | — | US | disclosed |
| EP-2877444-A1 | INHIBITORS OF HISTONE DEACETYLASE | The Broad Institute, Inc. (US) | 2015-06-03 | — | — | EP | disclosed |
| WO-2014018979-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE, INC. (US) | 2014-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072671-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC3, HDAC1, HDAC11 | HTR3E 2904/4885HTR3B 2945/4885HTR3A 3309/4885 |
| US-20150191427-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC3, HDAC1, HDAC5 | HTR3E 2855/4885HTR3B 2907/4885HTR3A 3269/4885 |
| US-11377423-B2 | Inhibitors of histone deacetylase | HDAC3, HDAC1, HDAC11 | HTR3E 2783/4885HTR3B 2850/4885HTR3A 3244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.