Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ILK | Q13418 | 1/20 | 0.74 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RXRG | P48443 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | LHCGR | P22888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17077261 | 0.92 | ILK (0.64) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL19839523 | 0.88 | ILK (0.68) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL17077245 | 0.87 | ILK (0.70) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL9105969 | 0.87 | ILK (0.67) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL17077247 | 0.85 | ILK (0.75) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL8536228 | 0.85 | ILK (1.00) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL17087633 | 0.85 | ILK (0.67) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL17087639 | 0.85 | ILK (0.67) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL23645917 | 0.84 | ILK (0.66) | ILKRXRARXRBRXRGALOX5 | |
| SCHEMBL17077248 | 0.84 | ILK (0.69) | ILKRXRARXRBRXRGALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11117888-B2 | Irreversible inhibitors of pyruvate kinase M2 and the use thereof | CHINA MEDICAL UNIVERSITY (TW) | 2021-09-14 | — | — | US | disclosed |
| US-20210221801-A1 | Irreversible inhibitors of pyruvate kinase M2 and the use thereof | CHINA MEDICAL UNIVERSITY (TW) | 2021-07-22 | — | — | US | disclosed |
| US-9457031-B2 | Antibacterial protein kinase inhibitors | OHIO STATE INNOVATION FOUNDATION | 2016-10-04 | — | — | US | disclosed |
| US-20150258100-A1 | ANTIBACTERIAL PROTEIN KINASE INHIBITORS | OHIO STATE INNOVATION FOUNDATION | 2015-09-17 | — | — | US | disclosed |
| EP-2879679-A2 | ANTIBACTERIAL PROTEIN KINASE INHIBITORS | The Ohio State University (US) | 2015-06-10 | — | — | EP | disclosed |
| WO-2014022382-A2 | ANTIBACTERIAL PROTEIN KINASE INHIBITORS | THE OHIO STATE UNIVERSITY (US) | 2014-02-06 | — | — | WO | disclosed |
| US-20100124550-A1 | AMIDE INHIBITORS OF RENIN | AUSPEX PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100124550-A1 | AMIDE INHIBITORS OF RENIN | REN, ACE, AGTR2 | ILK 3845/4885RXRA 2993/4885RXRB 2533/4885 |
| US-20210221801-A1 | Irreversible inhibitors of pyruvate kinase M2 and the use thereof | PDK2, PDK3, PDK4 | ILK 2678/4885RXRA 3747/4885RXRB 3482/4885 |
| US-11117888-B2 | Irreversible inhibitors of pyruvate kinase M2 and the use thereof | PDK2, PDK3, PDK4 | ILK 2678/4885RXRA 3747/4885RXRB 3482/4885 |
| US-20150258100-A1 | ANTIBACTERIAL PROTEIN KINASE INHIBITORS | DMPK, MYLK3, MYLK2 | ILK 1625/4885RXRA 3912/4885RXRB 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.