Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9082967 | 0.81 | TSHR (0.48) | SMN1; SMN2HPGDALDH1A1HTTGAA | |
| SCHEMBL11336551 | 0.79 | TSHR (0.47) | SMN1; SMN2HPGDALDH1A1HTTGAA | |
| SCHEMBL11081966 | 0.79 | ALDH1A1 (0.51) | PKMALDH1A1HTTGAAMEN1 | |
| SCHEMBL15568618 | 0.79 | PTGS2 (0.40) | SMN1; SMN2HPGDTP53PKMNPSR1 | |
| SCHEMBL15569145 | 0.79 | HTT (0.50) | ALDH1A1HTTRAB9ALMNATAS1R3 | |
| SCHEMBL13537202 | 0.78 | ALOX15 (0.40) | MAPTLMNATAS1R3TAS1R1 | |
| SCHEMBL8602478 | 0.76 | ALDH1A1 (0.53) | PKMALDH1A1HTTGAAMEN1 | |
| SCHEMBL7943214 | 0.76 | CYP3A4 (0.42) | SMN1; SMN2HPGDALDH1A1HTTGAA | |
| SCHEMBL11081975 | 0.75 | ALDH1A1 (0.51) | PKMALDH1A1HTTGAAMEN1 | |
| SCHEMBL17244464 | 0.75 | TAAR1 (0.41) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028669-A1 | NOVEL COMPOUNDS FOR MODULATION OF ROR-GAMMA ACTIVITY | BIOGEN IDEC MA INC. (US) | 2014-02-20 | — | — | WO | disclosed |