Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9082967 | 0.81 | TSHR (0.48) | HTTLMNAMAPK1KDM4EALDH1A1 | |
| SCHEMBL11336551 | 0.79 | TSHR (0.47) | HTTLMNAMAPK1KDM4EALDH1A1 | |
| SCHEMBL15568619 | 0.79 | SMN1; SMN2 (0.41) | HTTLMNARAB9ATAS1R3TAS1R1 | |
| SCHEMBL15569144 | 0.79 | HTT (0.46) | HTTLMNAMAPK1RAB9ATUBB1 | |
| SCHEMBL11081966 | 0.79 | ALDH1A1 (0.51) | HTTLMNATUBB1ALDH1A1 | |
| SCHEMBL13537202 | 0.78 | ALOX15 (0.40) | LMNAMAPK1TAS1R3TAS1R1KDM4E | |
| SCHEMBL3926817 | 0.77 | CES2 (0.41) | RAB9A | |
| SCHEMBL8602478 | 0.76 | ALDH1A1 (0.53) | HTTLMNATUBB1ALDH1A1 | |
| SCHEMBL28831953 | 0.76 | HDAC1 (0.42) | RAB9AERN1ALDH1A1 | |
| SCHEMBL17244464 | 0.75 | TAAR1 (0.41) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014028669-A1 | NOVEL COMPOUNDS FOR MODULATION OF ROR-GAMMA ACTIVITY | BIOGEN IDEC MA INC. (US) | 2014-02-20 | — | — | WO | disclosed |