Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 8/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29625514 | 0.83 | TAAR1 (0.58) | KMT2AHTR2AHTR6CYP1A2HTR1A | |
| SCHEMBL10822663 | 0.81 | KDM4E (0.49) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL11013421 | 0.81 | KDM4E (0.49) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL28023155 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BKDM4E | |
| SCHEMBL28960637 | 0.80 | HTR1A (0.58) | KMT2AHTR6CYP1A2HTR1ACYP2D6 | |
| SCHEMBL4009706 | 0.79 | HTR1D (0.44) | KMT2AHTR1AHTR1DHTR2C | |
| SCHEMBL7203389 | 0.78 | ALOX5 (0.48) | KMT2AMTNR1AMTNR1BHTR2BALDH1A1 | |
| SCHEMBL7209241 | 0.78 | ALOX5 (0.48) | KMT2AMTNR1AMTNR1BHTR2BALDH1A1 | |
| SCHEMBL29387252 | 0.76 | KDM4E (0.40) | MTNR1AKDM4EALDH1A1 | |
| SCHEMBL6826542 | 0.75 | HTR2A (0.54) | KMT2AHTR2AAOC3HTR6MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885284-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | Respivert Limited (GB) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014027209-A1 | PYRAZOLYL-UREAS AS KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2014-02-20 | — | — | WO | disclosed |