Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15567364 | 0.88 | PTGES (0.46) | PTGESMITFMAOBKDM4EALDH1A1 | |
| SCHEMBL15568125 | 0.78 | PTGES (0.75) | PTGESMITFMAOBKDM4EALDH1A1 | |
| SCHEMBL3326788 | 0.75 | PTGES (0.51) | PTGESMITFKDM4EALDH1A1POLB | |
| SCHEMBL5309603 | 0.75 | MAOB (0.60) | MAOBTNKSNPC1RAB9AMAOA | |
| SCHEMBL2370723 | 0.71 | MAPT (0.40) | MAOBKDM4EPOLBMAPTTDP1 | |
| SCHEMBL15775877 | 0.71 | RAB9A (0.51) | PTGESMITFMAOBKDM4EALDH1A1 | |
| SCHEMBL15568360 | 0.71 | CCNB2 (0.44) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL15567401 | 0.70 | PTGES (0.43) | PTGESMITFKDM4EALDH1A1MAPT | |
| SCHEMBL7264074 | 0.68 | F7 (0.40) | KDM4EALDH1A1POLBMAPTHPGD | |
| SCHEMBL1424093 | 0.65 | PRKCA (0.45) | PTGESMITFKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882714-B1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-11-13 | — | — | EP | disclosed |
| EP-2882714-B1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-11-13 | — | — | EP | disclosed |
| US-9376433-B2 | (AZA-)isoquinolinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-9376433-B2 | (AZA-)isoquinolinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-9376433-B2 | (AZA-)isoquinolinone derivatives | MERCK PATENT GMBH (DE) | 2016-06-28 | — | — | US | disclosed |
| US-20150210686-A1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150210686-A1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150210686-A1 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-07-30 | — | — | US | disclosed |
| EP-2882714-A2 | (AZA-)ISOQUINOLINONE DERIVATIVES | Merck Patent GmbH (DE) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023390-A2 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-02-13 | — | — | WO | disclosed |
| WO-2014023390-A2 | (AZA-)ISOQUINOLINONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210686-A1 | (AZA-)ISOQUINOLINONE DERIVATIVES | TANK, TNKS, TDP1 | PTGES 767/4885MITF 3345/4885MAOB 751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.